A PhD student position in bioinformatics / computational biology funded for 3 years to study the role of glial cells in Huntington disease is available at the CEA / MIRCEN research centre in Paris. This project will provide novel insight into the molecular changes occurring in glial cells during HD and identify endogenous protective glial responses, amenable to therapeutic improvement.
Knowledge : Training in bioinformatics, including on experimental methods and analysis software and algorithms for RNA-seq and functional genomics. Knowledge in statistics, data mining and reporting. A complementary training in Neuroscience (molecular or cellular neuroscience, neuropathology or methods in neuroscience) would be an asset.
Skills : Expertise in bioinformatics tools for RNA-seq data analysis (e.g. Hisat2, featureCounts, htseq-counts, DESeq2). Very good knowledge of the R and Bioconductor environment required. Familiarity with Linux and cluster environments (such as Slurm). Experience with the analysis of other “omics” data, such as proteomics and/or knowledge in the field of systems biology, more precisely biological networks inference and analysis would be an asset for the position.
The candidate should demonstrate communication ability and be willing to work in an interdisciplinary environment.
The candidate will be co-supervised by Dr. Carole Escartin (MIRCen, Fontenay-aux-Roses, France, head of the reactive astrocyte team, and an expert in glial cells, Huntington’s disease and cellular neuroscience, http://jacob.cea.fr/drf/ifrancoisjacob/english/Pages/Departments/MIRCen/ResearchThemes/Reactive-astrocytes.aspx) and Dr. Eric Bonnet (CNRGH, Evry, France, head of the bioanalysis group, expert in bioinformatics, http://eric.d.bonnet.free.fr/ and
http://jacob.cea.fr/drf/ifrancoisjacob/english/Pages/Departments/CNRGH/Laboratories/bioanalysis.aspx). The PhD candidate will spend most of his/her time in Fontenay-aux-Roses but will also regularly go to Evry to benefit from the expert environment in genomics and bioinformatics. Candidates who are willing to also learn and take part in animal and biological experiments are welcome. This PhD project will benefit from a secured fellowship from the CEA (Amont-Aval Program, 3 years funding).
Start date: 1/10/2019
Application deadline: 15/05/2019